Languedoc - Roussillon wine, including the vin de pays labeled Vin de Pays d'Oc, is produced in southern France. While "Languedoc" can refer to a specific historic region of France and Northern Catalonia, usage since the 20th century (especially in the context of wine) has primarily referred to the northern part of the Languedoc-Roussillon région of France, an area which spans the Mediterranean coastline from the French border with Spain to the region of Provence. The area has around 700,000 acres (2,800 km2) under vines and is the single biggest wine-producing region in the world, being responsible for more than a third of France's total wine production.

The Languedoc-Roussillon area is home to numerous grape varieties, including many international varieties like Merlot, Cabernet Sauvignon but the traditional Rhône grapes of Mourvedre, Grenache and Syrah are prominent, along with Carignan and Cinsault. Some of the more recognised areas include Corbières, Faugères, Fitou, and Minervois AOCs.

The Languedoc-Roussillon area is home to numerous grape varieties, including many international varieties like Sauvignon Blanc, Chardonnay and Viognier which are increasing their foothold in the region.

Chardonnay is the major white grape, used in the Vin de Pays d'Oc and the sparkling Crémant de Limoux. Others include Chenin Blanc and Mauzac, which is also the principal grape in the sparkling Blanquette de Limoux. The sweet fortified wines of the Muscat de Frontignan and Muscat de St-Jean Minervois regions are made with the Muscat Blanc à Petits Grains grapes. In the Muscat de Rivesaltes AOC, fortified wines are made from Muscat of Alexandria grapes. Other varieties that can be found include Roussanne, Marsanne, Vermentino, Bourboulenc, Clairette, Grenache Blanc, Grenache gris, Picpoul, Maccabéo and Rolle.